Naltrexone was approved by the FDA in 1984 to treat opioid addiction. It is an opioid receptor antagonist approved to treat drug addiction. In the late 80s, Dr. Bihari treated this patient population with Naltrexone.  He found that at high doses (50 to 100 mgs), Naltrexone caused significant depression as a side effect. However at low doses (.5 mg up to 4 mg) he found it to be effective for not only mental health, but a multitude of symptoms (joints, skin, mood, pain, inflammation ) without the side effects of depression.

Since then the patent has run out, but there are generic Naltrexone capsules and tablets in 25 mg or 50 mg on the market to treat drug addiction presently. The compiled Data has shown that LDN is effective use for adjunctive therapy for cancer and a multitude of autoimmune conditions.

LDN is a pure inhibitor so it has no narcotic effects. The chemical structure is nearly identical to endorphin which is made naturally in our body. LDN at ( .4 to 4mg ) this very low dose, exert a slow but definite hermesis effect to help increase the natural endorphin made in our body to exact its multitude of beneficial effects.

My own experience with LDN has been positive for all of my autoimmune symptoms (brain fog, sleep, skin, joints,mood). I started out taking 0.5 for 1 week, then increase to 1 mg at night, gradually went up to 3 mg a night for steady base for a couple of years.  Currently, after in a relative healthy place, I  tapered LDN to a baseline of 1.75 mg before bed time nitely.  My yardstick for LDN is a hint of a small headache. that is when I know to decrease LDN another increment.  I had my physician order Naltrexone 25 mg capsule. I then reduce the strength with 25 dropper full of distill water. 1 dropper full is equal to 1 mg then.